Sesquiterpene Lactones, Acyl Phenyl Propanoids and Other Constituents from Schkuhria pinnata var. wislizeni. Antioxidant Evaluation
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چکیده
Chemical investigation of aerial parts of Schkuhria pinnata var wislizeni (Asteraceae) allowed the characterization of the sesquiterpene lactones 1, 2 and 5, the flavonoids 3 and 4, and the acyl phenyl propanoids 10 and 11. Structure 2, named dischkuhriolin, was confirmed as a Diels Alder adduct of 1 as dienophile and a guaianolide as diene. Spectroscopic analysis of 5 and its diacetyl derivative allowed the structural correction of compounds previously reported from Schkuhria. 2, 10 and 11 are new natural compounds. Biological assays indicated that the mixture 10 + 11 showed antioxidant activity expressed as inhibition of AAPH-induced damage in rat pancreatic homogenate.
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